If you changed caching settings in the TCM54.config file in the web\WebUI\Models\TCM54\Configuration\ subfolder of %TRIDION_HOME% (defaults to C:\Program Files (x86)\Tridion\), back it up to a safe location.
TCM54.config
%TRIDION_HOME%
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Backing up CME.config
Preparing to upgrade SiteEdit to Experience Manager
Reconfiguring the Content Manager Explorer Web site
Configuring the Content Manager Explorer Web site
Preparing for the Content Manager server upgrade
Configuring a caching folder for user profile pictures